Intramolecular nitrile oxide-alkene cycloaddition of sugar derivatives with unmasked hydroxyl group(s).

@article{Shing2007IntramolecularNO,
  title={Intramolecular nitrile oxide-alkene cycloaddition of sugar derivatives with unmasked hydroxyl group(s).},
  author={Tony Kung Ming Shing and Wai F. Wong and Hau Man Cheng and Wun S. Kwok and King Ho So},
  journal={Organic letters},
  year={2007},
  volume={9 5},
  pages={
          753-6
        }
}
[reaction: see text] Intramolecular nitrile oxide-alkene cycloaddition (INOC) of sugar derivatives with one to four free hydroxyl group(s) is reported. The INOC reaction, using chloramine-T, in the presence of silica gel, to generate nitrile oxides from oximes, proceeded smoothly to afford five- or six-membered carbocycles in good to excellent yields. This new methodology alleviates protection/deprotection steps and makes the synthetic route shorter and more efficient. 
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