Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.

@article{Ponsaerts2010IntramolecularLI,
  title={Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.},
  author={Raf Ponsaerts and Elke De Vuyst and Mauricio Retamal and Catheleyne D'hondt and Dieter Vermeire and Nan Wang and Humbert de Smedt and Pascale Zimmermann and Bernard Himpens and Johan Vereecke and Luc Leybaert and Geert Bultynck},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 11},
  pages={
          4378-95
        }
}
Connexin-assembled gap junctions (GJs) and hemichannels coordinate intercellular signaling processes. Although the regulation of connexins in GJs has been well characterized, the molecular determinants controlling connexin-hemichannel activity are unresolved. Here we investigated the regulation of Cx43-hemichannel activity by actomyosin contractility and intracellular [Ca(2+)] ([Ca(2+)](i)) using plasma membrane-permeable TAT peptides (100 μM) designed to interfere with interactions between the… CONTINUE READING

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Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala.

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