Intramolecular cyclopropanation of glycals: studies toward the synthesis of canadensolide, sporothriolide, and xylobovide.

@article{Yu2001IntramolecularCO,
  title={Intramolecular cyclopropanation of glycals: studies toward the synthesis of canadensolide, sporothriolide, and xylobovide.},
  author={M. Yu and V. Lynch and B. Pagenkopf},
  journal={Organic letters},
  year={2001},
  volume={3 16},
  pages={
          2563-6
        }
}
  • M. Yu, V. Lynch, B. Pagenkopf
  • Published 2001
  • Chemistry, Medicine
  • Organic letters
  • [reaction: see text] The first examples of copper-catalyzed intramolecular cyclopropanations of glycal-derived diazoacetates are reported. The new cyclopropanes are converted into advanced intermediates for the synthesis of bislactone natural products. Synthetic highlights include the selective monodeprotection of a di-tert-butylsilylene ether and a zinc-mediated ring opening cascade reaction. 
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