Intramolecular cycloaddition reactions of furo[3,4-b]indoles for alkaloid synthesis.

Abstract

Model studies dealing with the Cu(II)- or Rh(II)-catalyzed carbenoid cyclization/cycloaddition cascade of several α-diazo indolo amido esters have been carried out as an approach to the alkaloid scandine. The Cu(II)-catalyzed reaction of an α-diazo indolo diester that contains a tethered oxa-pentenyl side chain was found to give rise to a reactive benzo[c… (More)
DOI: 10.1021/jo500331j

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