Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor gamma coactivator 1alpha.

@article{Sano2007IntramolecularCO,
  title={Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor gamma coactivator 1alpha.},
  author={Motoaki Sano and Satori Tokudome and Noriaki Shimizu and Noritada Yoshikawa and Chie Ogawa and Kousuke Shirakawa and Jin Endo and Takaharu Katayama and Shinsuke Yuasa and Masaki Ieda and Shinji Makino and F. Hattori and Hirotoshi Tanaka and Keiichi Fukuda},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 35},
  pages={25970-80}
}
Peroxisome proliferator-activated receptor gamma coactivator (PGC)-1 is a critical transcriptional regulator of energy metabolism. Here we found that PGC-1alpha is a short lived and aggregation-prone protein. PGC-1alpha localized throughout the nucleoplasm and was rapidly destroyed via the ubiquitin-proteasome pathway. Upon proteasome inhibition, PGC-1alpha formed insoluble polyubiquitinated aggregates. Ubiquitination of PGC-1alpha depended on the integrity of the C terminus-containing arginine… CONTINUE READING