Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

  title={Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1},
  author={Jiangyu Zhu and Futoshi Shibasaki and Roydon Price and J C Guillemot and Takeo Yano and Volker D{\"o}tsch and Gerhard Wagner and Pascual Ferrara and Frank McKeon},
T cell activation requires the import of NF-AT transcription factors to the nucleus, a process promoted by calcineurin-dependent dephosphorylation and inhibited by poorly understood protein kinases. Here, we report the identification of two protein kinases that oppose NF-AT4 nuclear import. Casein kinase Ialpha directly binds and phosphorylates NF-AT4, resulting in the inhibiton of NF-AT4 nuclear translocation. MEKK1 indirectly suppresses NF-AT4 nuclear import by stabilizing the interaction… CONTINUE READING
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