Intramitochondrial phospholipase activity and the effects of Ca2+ plus N-ethylmaleimide on mitochondrial function.

@article{Pfeiffer1979IntramitochondrialPA,
  title={Intramitochondrial phospholipase activity and the effects of Ca2+ plus N-ethylmaleimide on mitochondrial function.},
  author={Douglas R. Pfeiffer and Patricia C. Schmid and M C Beatrice and Harald H. O. Schmid},
  journal={The Journal of biological chemistry},
  year={1979},
  volume={254 22},
  pages={11485-94}
}
Liver mitochondria treated with N-ethylmaleimide can accumulate Ca2+ but cannot retain it. Ca2+ loss following uptake occurs in parallel with a proton uptake and collapse of the membrane potential. Respiration is not activated during Ca2+ release and cannot be stimulated by uncoupler. After Ca2+ release and accompanying phenomena are nearly complete, the mitochondria undergo a large amplitude swelling. Nupercaine inhibits the premature release of Ca2+, proton uptake, decline in membrane… CONTINUE READING

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