Intramembrane charge movements and excitation– contraction coupling expressed by two-domain fragments of the Ca21 channel


To investigate the molecular basis of the voltage sensor that triggers excitation–contraction (EC) coupling, the four-domain pore subunit of the dihydropyridine receptor (DHPR) was cut in the cytoplasmic linker between domains II and III. cDNAs for the I-II domain (a1S 1–670) and the III-IV domain (a1S 701-1873) were expressed in dysgenic a1S-null myotubes… (More)


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