Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms.

@article{Rttimann2009IntramealHP,
  title={Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms.},
  author={Elisabeth B R{\"u}ttimann and Myrtha M Arnold and Jacquelien J G Hillebrand and Nori Geary and Wolfgang Langhans},
  journal={Endocrinology},
  year={2009},
  volume={150 3},
  pages={1174-81}
}
Peripheral administration of glucagon-like peptide (GLP)-1 reduces food intake in animals and humans, but the sites and mechanism of this effect and its physiological significance are not yet clear. To investigate these issues, we prepared rats with chronic catheters and infused GLP-1 (0.2 ml/min; 2.5 or 5.0 min) during the first spontaneous dark-phase meals. Infusions were remotely triggered 2-3 min after meal onset. Hepatic portal vein (HPV) infusion of 1.0 or 3.0 (but not 0.33) nmol/kg GLP-1… CONTINUE READING
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