Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections.

  title={Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections.},
  author={Gabriela Senti and Reto Crameri and Daniela Kuster and P{\aa}l Johansen and Julia M Mart{\'i}nez-G{\'o}mez and Nicole L Graf and Martin Steiner and L. A. Hothorn and Hans Gr{\"o}nlund and Christine Tivig and Anna Zaleska and Ozge Uysal Soyer and Marianne van Hage and Cezmi A. Akdis and M{\"u}beccel Akdis and Horst Rose and Thomas M. K{\"u}ndig},
  journal={The Journal of allergy and clinical immunology},
  volume={129 5},
BACKGROUND Subcutaneous allergen-specific immunotherapy frequently causes allergic side effects and requires 30 to 80 injections over 3 to 5 years. OBJECTIVE We sought to improve immunotherapy by using intralymphatic allergen administration (intralymphatic immunotherapy [ILIT]) and by targeting allergen to the MHC class II pathway. METHODS Recombinant major cat dander allergen Fel d 1 was fused to a translocation sequence (TAT) and to part of the human invariant chain, generating a modular… CONTINUE READING
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