Intralymphatic immunization enhances DNA vaccination.

  title={Intralymphatic immunization enhances DNA vaccination.},
  author={Kevin J Maloy and Iris Erdmann and Veronique Basch and Sophie Sierro and Thomas Kramps and Rolf Martin Zinkernagel and Stephan Oehen and Thomas M. K{\"u}ndig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 6},
Although DNA vaccines have been shown to elicit potent immune responses in animal models, initial clinical trials in humans have been disappointing, highlighting a need to optimize their immunogenicity. Naked DNA vaccines are usually administered either i.m. or intradermally. The current study shows that immunization with naked DNA by direct injection into a peripheral lymph node enhances immunogenicity by 100- to 1,000-fold, inducing strong and biologically relevant CD8(+) cytotoxic T… CONTINUE READING


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