Intrakines--evidence for a trans-cellular mechanism of action.

  title={Intrakines--evidence for a trans-cellular mechanism of action.},
  author={Barbara C Engel and Gerhard Bauer and Karen A. Pepper and David Bockstoce and Xiao Jiong Yu and Si Yi Chen and Donald B Kohn},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={1 2},
Human CXCR4 is the receptor for the CXC chemokine SDF-1alpha and also acts as a coreceptor for T lymphotropic HIV-1 strains. Blocking the surface expression of this receptor via an intrakine approach has recently been shown to efficiently prevent HIV-1 infection of T cells. The CXC-chemokine gene is fused to an endoplasmic reticulum retention signal (KDEL) that retains the newly synthesized chemokine and its receptor within the cell, where both are subsequently degraded. We constructed MoMuLV… CONTINUE READING


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