Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats.
@article{Okuma2016IntrajejunalIO, title={Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats.}, author={Chihiro Okuma and Takeshi Ohta and Makoto Ito and Hironobu Tadaki and Tomohiro Oda and Shinichi Kume and Jun Nishiu and Makoto Kakutani}, journal={Journal of pharmacological sciences}, year={2016}, volume={130 2}, pages={ 136-8 } }
4 Citations
Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice
- Medicine, BiologyGut
- 2020
BAs regulate gastric emptying and satiation by determining fat-dependent GPR119 activity in distal intestine by regulating the quantity and localisation of hydrolysed fat in small intestine.
The python-derived 16α-hydroxylated bile acid, pythocholic acid decreases food intake and increases jejunal fatty acid ethanolamides in mice
- BiologybioRxiv
- 2022
The exogenous bile acid pythocholic acid is a novel regulator of food intake and the satiety signal OEA in the mouse intestine and is greater than the effects of DCA.
2-Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC-1 cells via cannabinoid receptor CB1.
- BiologyLipids
- 2021
Results indicate that a specific 2-MAG, 2-AG, directly stimulates CCK secretion via cannabinoid receptor 1 (CB1) via CB1 in a dose-dependent manner.
Usefulness of Obese Animal Models in Antiobesity Drug Development
- Biology, Medicine
- 2017
The characteristics of obeseAnimal models and the results of pharmacological studies using obese animal models for new antiobesity drugs are shown.
References
SHOWING 1-10 OF 16 REFERENCES
Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length.
- Medicine, BiologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2004
There are major differences in the effects of intraduodenal C12 and C10, administered at 0.375 kcal/min, on appetite, energy intake, antropyloroduodanal PWs, and gut hormone release in humans.
Effects of small-intestinal fat and carbohydrate infusions on appetite and food intake in obese and nonobese men.
- Medicine, BiologyThe American journal of clinical nutrition
- 1999
Intraduodenal infusions of fat suppressed appetite and food intake more than did equienergetic infusion of carbohydrate in both obese and nonobese young men, and the responses to intraduODenal fat and glucose were not affected by obesity.
Effects of duodenal and distal ileal infusions of glucose and oleic acid on meal patterns in rats.
- Medicine, BiologyThe American journal of physiology
- 1995
The dose-dependent effects of duodenal and distal ileal infusions of glucose and oleic acid on meal patterns in ad libitum feeding rats are determined to suggest that ILEal oleoic acid and glucose suppress feeding by different mechanisms and that these mechanisms differ from those mediating the anorexic responses to oleiatic Acid and glucose in the duodenum.
Carbohydrates and human appetite.
- BiologyThe American journal of clinical nutrition
- 1994
The experimental evidence suggests that it is possible to design high-carbohydrate diets that provide good nutrition with adequate control over appetite and a beneficial effect on body weight.
Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity
- Biology, MedicinePloS one
- 2012
A role for intestinal MGL, and intestinal 2-AG and perhaps other MG species, in whole body energy balance via regulation of food intake as well as metabolic rate is suggested.
Inhibition of ileal water absorption by intraluminal fatty acids. Influence of chain length, hydroxylation, and conjugation of fatty acids.
- Chemistry, MedicineThe Journal of clinical investigation
- 1974
It is speculated that the phenomenon of inhibition of water and electrolyte absorption by fatty acids may be relevant to steatorrhea and diarrhea in man.
Malabsorption of long-chain fatty acid in cholera toxin-induced secretory diarrhea
- Biology, MedicineDigestive Diseases and Sciences
- 2005
The results suggest that intestinal secretion induced by cholera toxin may delay the mucosal uptake and lymphatic transport of long-chain fatty acids.
JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity.
- BiologyEuropean journal of pharmacology
- 2015
The role of protein in weight loss and maintenance.
- MedicineThe American journal of clinical nutrition
- 2015
Data suggest that higher-protein diets that contain between 1.2 and 1.6 g protein · kg-1 · d-1 and potentially include meal-specific protein quantities of at least ∼25-30 g protein/meal provide improvements in appetite, body weight management, cardiometabolic risk factors, or all of these health outcomes; however, further strategies to increase dietary compliance with long-term dietary interventions are warranted.
The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man.
- MedicineGut
- 1984
Observations show the existence in man of an inhibitory intestinal control mechanism, whereby ileal fat perfusion inhibits jejunal motility and delays caudal transit of jeJunal contents.