Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response.

Because absence of the glucagon response to falling plasma glucose concentrations plays a key role in the pathogenesis of iatrogenic hypoglycemia in patients with insulin-deficient diabetes and the mechanism of this defect is unknown, and given evidence in experimental animals that a decrease in intraislet insulin is a signal to increased glucagon secretion… CONTINUE READING