Intraintestinal toxin in infant mice challenged intragastrically with Clostridium botulinum spores.

@article{Sugiyama1978IntraintestinalTI,
  title={Intraintestinal toxin in infant mice challenged intragastrically with Clostridium botulinum spores.},
  author={Hiroshi Sugiyama and D C Mills},
  journal={Infection and immunity},
  year={1978},
  volume={21 1},
  pages={59-63}
}
Conventionally raised suckling mice were injected intragastrically with 10(5) spores of a Clostridium botulinum type A culture. Botulism was not observed, but 80% or more of mice challenged when 8 to 11 days old had botulinum toxin in the large intestine 3 days later. Mice younger than 7 days or older than 15 days were resistant to the challenge. When in vivo toxin production was started by spores given to 9-day-old mice, toxin was present in the intestine at 1 through 7 days postchallenge but… CONTINUE READING

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