Intrahippocampal infusion of an inhibitor of protein kinase A separates short- from long-term memory.

@article{Vianna1999IntrahippocampalIO,
  title={Intrahippocampal infusion of an inhibitor of protein kinase A separates short- from long-term memory.},
  author={Monica Ryff Moreira Vianna and Luciana A. Izquierdo and Daniela Mart{\'i} Barros and Jorge Horacio Medina and Ivan A. Izquierdo},
  journal={Behavioural pharmacology},
  year={1999},
  volume={10 2},
  pages={223-7}
}
Rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus were trained in one-trial step-down inhibitory (passive) avoidance, and tested for short- and long-term memory of this task at 1.5-3.0 and at 24 h from training, respectively. At various times after training (0, 22, 45, 90, 135 or 175 min) they received a 0.5 microl infusion of the protein kinase A (PKA) inhibitor, KT5720 (0.1 or 0.5 microg), or of its vehicle (20% dimethylsulfoxide in saline). At the higher… CONTINUE READING

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