Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection.

@article{Abel2006IntrahepaticVI,
  title={Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection.},
  author={Michal Abel and Damien S{\`e}ne and Stanislas Pol and Marc Bourli{\`e}re and Thierry Poynard and Fr{\'e}d{\'e}ric Charlotte and Patrice Cacoub and Sophie Caillat-Zucman},
  journal={Hepatology},
  year={2006},
  volume={44 6},
  pages={1607-16}
}
CD8 T cell killing of hepatitis C virus (HCV)-infected hepatocytes is thought to contribute to liver damage during chronic HCV infection, whereas the participation of HCV-nonspecific immune cells is unclear. To visualize the spatial relationship of HCV-specific CD8 T cells with parenchymal target cells, and to examine their local functional activity in relation to hepatocellular necrosis and fibrosis, we used HLA tetramers and confocal microscopy in biopsies from 23 HLA-A2 or HLA-B7 patients… CONTINUE READING
53 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

Similar Papers

Loading similar papers…