Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver.

@article{Meier2006IntrahepaticTI,
  title={Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver.},
  author={Juris J Meier and Irene Hong-McAtee and Ryan Galasso and Johannes D. Veldhuis and Antoinette Moran and Bernhard J. Hering and Peter C Butler},
  journal={Diabetes},
  year={2006},
  volume={55 8},
  pages={2324-32}
}
Intrahepatic islet transplantation is an experimental therapy for type 1 diabetes. In the present studies, we sought to address the following questions: 1) In humans, do intrahepatic transplanted islets reestablish coordinated puslatile insulin secretion? and 2) To what extent is insulin secreted by intrahepatic transplanted islets delivered to the hepatic sinusoids (therefore effectively restoring a portal mode of insulin delivery) versus delivered to the hepatic central vein (therefore… CONTINUE READING
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