Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B

@article{Chen2010IntrahepaticLO,
  title={Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B},
  author={Ji Chen and Xiao-mei Wang and X Wu and Yan Wang and Hong Zhao and Bing Shen and Gui-qiang Wang},
  journal={Inflammation Research},
  year={2010},
  volume={60},
  pages={47-53}
}
  • Ji Chen, Xiao-mei Wang, +4 authors Gui-qiang Wang
  • Published in Inflammation Research 2010
  • Medicine
  • Background and objectiveProgramed cell death-1 (PD-1) represents a mechanism of T-cell dysfunction in hepatitis B virus (HBV) persistence. In peripheral blood, PD-1 is up-regulated in virus-specific T cells, leading to the impairment of T cells. This study investigated the intrahepatic expression of PD-1 and its ligand (PD-L) in patients with chronic hepatitis B (CHB) virus.MethodsLiver specimens were obtained from CHB (n = 56), acute hepatitis B (AHB, n = 12) patients and age-matched healthy… CONTINUE READING

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