Intrahepatic distribution of hydrochlorothiazide and quinidine in rats: implications in pharmacokinetics.

@article{Abdelhameed1993IntrahepaticDO,
  title={Intrahepatic distribution of hydrochlorothiazide and quinidine in rats: implications in pharmacokinetics.},
  author={Mohammad Abdelhameed and T. M. Chen and Win L. Chiou},
  journal={Journal of pharmaceutical sciences},
  year={1993},
  volume={82 10},
  pages={
          992-6
        }
}
The intrahepatic distributions of a nonmetabolized drug, hydrochlorothiazide (HCTZ) and a highly metabolized drug, quinidine (QD), were studied separately in five anesthetized rats during steady-state intravenous infusion. Liver samples (20-24) from various parts (0.1-0.2 g each) at the end of infusion were collected from each rat and analyzed for drug concentration by HPLC. The distribution of HCTZ in various macro regions appears quite "homogeneous," with a CV of drug concentration for each… 
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