Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: report of two cases and review of the literature.

@article{Xu2009IntrahepaticCA,
  title={Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: report of two cases and review of the literature.},
  author={Aimin Xu and Zhi-hong Xian and Shu-hui Zhang and Xin-Fang Chen},
  journal={European journal of gastroenterology & hepatology},
  year={2009},
  volume={21 5},
  pages={580-4}
}
Multiple bile duct hamartomas (BDHs)/von Meyenburg complexes, are tumor-like lesions of the liver. Malignant transformation in BDHs has been previously reported in very rare instances, and the most common tumor arising in this clinical setting is cholangiocarcinoma. Herein, we report on clinicopathological findings in two cases of cholangiocarcinoma occurring in liver with multiple BDHs. Histopathologically, multiple BDHs showed morphologic transition from clearly benign to dysplasia or… CONTINUE READING