Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy

  title={Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy},
  author={Francesco Donato and Umberto Gelatti and Alessandro Tagger and Maurizio Favret and Maria Lisa Ribero and Francesco Callea and Claudia Martelli and Antonella Savio and Paola Trevisi and Giuseppe Nardi},
  journal={Cancer Causes \& Control},
Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case–control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995–2000, 26 (7%) ICC cases were identified. A total of 824… 

Risk Factors for Intrahepatic and Extrahepatic Cholangiocarcinoma: A Hospital-Based Case–Control Study

Liver cirrhosis and chronic HCV infection are possible risk factors for ICC but not ECC, and heavy alcohol consumption is a risk factor for both ICC and ECC.

Hepatitis B Virus Infection and Intrahepatic Cholangiocarcinoma in Korea: A Case-Control Study

The results indicate that development of ICC seems to be more closely related to HBV infection than to HCV infection in Korea, where both HBV and ICC are endemic.

Bile Duct Dysplasia in the Setting of Chronic Hepatitis C and Alcohol Cirrhosis

Dysplasia can be found within the intrahepatic bile ducts in chronicHCV cirrhosis, supporting recent epidemiologic studies identifying chronic HCV as a major risk factor for intra hepatic cholangiocarcinoma.

Clinicopathological comparison between intrahepatic cholangiocarcinoma arising in livers positive and negative for hepatitis B or C virus

The clinicopathological features and the prognosis after the surgical treatment of ICCs arising from livers with and without hepatitis B virus (HBV) or hepatitis C virus (HCV) are compared, with an aim of clarifying the impact of HBV or HCV infection on the development of ICC and on the prognostic of patients.

Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population‐based study of U.S. veterans

It is indicated that HCV infection conferred a more than twofold elevated risk of ICC and a significant association with pancreatic cancer was erased by alcohol use and other variables.

Risk of Hepatobiliary and Pancreatic Cancers Following Hepatitis C Virus Infection

The risk of HCC associated with HCV was very high, and adjustment for cirrhosis, diabetes, inflammatory bowel disease, hepatitis B, alcoholism, and alcoholic liver disease did not reduce the risk for ICC below twofold.

Hepatitis C virus infection and the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma: evidence from a systematic review and meta-analysis of 16 case-control studies

HCV infection is associated with the increasing risk of CCA, especially ICC, and the pooled risk estimate of ICC in studies from North America was obviously higher than in Asia.

[The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study].

There was no significant association between seropositivity for HBsAg or anti-HCV and PC and further studies are warranted to clarify the association between HBV infection and PC in regions where HBV is endemic.



Hepatitis B and C virus infection, alcohol drinking, and hepatocellular carcinoma: A case‐control study in Italy

Positive interactions (synergisms) between both HBsAg positivity and HCV RNApositivity and heavy alcohol intake were found, suggesting more than additive effects of viral infections and alcohol drinking on the risk of HCC.

Hepatitis B and C virus, Clonorchis sinensis for the risk of liver cancer: a case-control study in Pusan, Korea.

Strong evidence indicated that both HBV and HCV infection were independent risk factors for HCC in Korea, and C. sinensis in stools and heavy drinking were associated with the risk of CLG in Korea.

Hepatitis C virus genotypes in patients with hepatocellular carcinoma and cholangiocarcinoma in Thailand.

Case‐control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma: The role of HCV genotypes and the synergism with hepatitis B virus and alcohol

A case‐control study to evaluate the risk of hepatocellular carcinoma (HCC) for hepatitis C virus (HCV) infection and HBV infection and alcohol intake in Brescia, North Italy found synergism was found.

Risk factors and clinical presentation of hepatobiliary carcinoma in patients with primary sclerosing cholangitis: A case‐control study

Clinical and biochemical presentation of PSC patients with and without hepatobiliary carcinoma did not differ during the year before cancer diagnosis/Ltx, and smoking seems to be a risk factor for developing hepatobility carcinoma in patients with PSC.

Incidence, etiologic aspects and clinicopathologic features in intrahepatic cholangiocellular carcinoma--a study of 51 cases from a low-endemicity area.

A total of 51 cases (19 males and 32 females) of intrahepatic cholangiocellular carcinoma (CCC) from a low-endemicity area of primary liver cancer was analyzed during the periods from 1958 to 1979

Liver cancer in Thailand. I. A case‐control study of cholangiocarcinoma

The results suggest that males may be at higher risk than females for cholangiocarcinoma, and regular users of betel nut had a high risk, a possible mechanism being through their increased exposure to nitro‐samines.

Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria--an epidemiological investigation.

Environmental factors of possible aetiological importance for primary liver carcinoma (PLC) in males were analysed in a case-control study including 83 cases of hepatocellular carcinoma and six cases with PLC had polyphyria cutanea tarda (PCT), which in 4 cases was related to alcoholism and in one case to haemochromatosis.

Hepatolithiasis associated with cholangiocarcinoma

Patients with hepatolithiasis should be kept in mind if there are high levels of CEA, if the location of the stones is classified as type I-L, or if portal veins cannot be seen on portograms, and liver resection should be considered because there may be undiagnosed cholangiocarcinoma.

[Epidemiology of hepatocellular carcinoma].

In addition to HBV infection, cirrhosis, aflatoxins, alcohol, tobacco smoking and oral contraceptives have been evaluated as risk factors for HCC; the importance of the contribution of these risk factors to the development of HCC and the perspectives for prevention in different geographical areas will be discussed.