Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy

@article{Donato2004IntrahepaticCA,
  title={Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy},
  author={Francesco Donato and Umberto Gelatti and Alessandro Tagger and Maurizio Favret and Maria Lisa Ribero and Francesco Callea and Claudia Martelli and Antonella Savio and Paola Trevisi and Giuseppe Nardi},
  journal={Cancer Causes \& Control},
  year={2004},
  volume={12},
  pages={959-964}
}
Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case–control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995–2000, 26 (7%) ICC cases were identified. A total of 824… 

Risk Factors for Intrahepatic and Extrahepatic Cholangiocarcinoma: A Hospital-Based Case–Control Study

Liver cirrhosis and chronic HCV infection are possible risk factors for ICC but not ECC, and heavy alcohol consumption is a risk factor for both ICC and ECC.

Hepatitis B Virus Infection and Intrahepatic Cholangiocarcinoma in Korea: A Case-Control Study

The results indicate that development of ICC seems to be more closely related to HBV infection than to HCV infection in Korea, where both HBV and ICC are endemic.

Bile Duct Dysplasia in the Setting of Chronic Hepatitis C and Alcohol Cirrhosis

Dysplasia can be found within the intrahepatic bile ducts in chronicHCV cirrhosis, supporting recent epidemiologic studies identifying chronic HCV as a major risk factor for intra hepatic cholangiocarcinoma.

Clinicopathological comparison between intrahepatic cholangiocarcinoma arising in livers positive and negative for hepatitis B or C virus

The clinicopathological features and the prognosis after the surgical treatment of ICCs arising from livers with and without hepatitis B virus (HBV) or hepatitis C virus (HCV) are compared, with an aim of clarifying the impact of HBV or HCV infection on the development of ICC and on the prognostic of patients.

Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population‐based study of U.S. veterans

It is indicated that HCV infection conferred a more than twofold elevated risk of ICC and a significant association with pancreatic cancer was erased by alcohol use and other variables.

Risk of Hepatobiliary and Pancreatic Cancers Following Hepatitis C Virus Infection

The risk of HCC associated with HCV was very high, and adjustment for cirrhosis, diabetes, inflammatory bowel disease, hepatitis B, alcoholism, and alcoholic liver disease did not reduce the risk for ICC below twofold.

Hepatitis C virus infection and the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma: evidence from a systematic review and meta-analysis of 16 case-control studies

HCV infection is associated with the increasing risk of CCA, especially ICC, and the pooled risk estimate of ICC in studies from North America was obviously higher than in Asia.

[The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study].

There was no significant association between seropositivity for HBsAg or anti-HCV and PC and further studies are warranted to clarify the association between HBV infection and PC in regions where HBV is endemic.
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