Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj.

  title={Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj.},
  author={Teagan J. Walter and Charles P Vanderpool and Ashley E. Cast and Stacey S. Huppert},
  journal={The American journal of pathology},
  volume={184 5},
The potential for intrahepatic bile duct (IHBD) regeneration in patients with bile duct insufficiency diseases is poorly understood. Notch signaling and Hnf6 have each been shown to be important for the morphogenesis of IHBDs in mice. One congenital pediatric liver disease characterized by reduced numbers of IHBDs, Alagille syndrome, is associated with mutations in Notch signaling components. Therefore, we investigated whether liver cell plasticity could contribute to IHBD regeneration in mice… CONTINUE READING


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