Intrahepatic and intramyocellular lipids are determinants of insulin resistance in prepubertal children

@article{LarsonMeyer2010IntrahepaticAI,
  title={Intrahepatic and intramyocellular lipids are determinants of insulin resistance in prepubertal children},
  author={Dawnine Enette Larson-Meyer and Bradley R. Newcomer and Eric Ravussin and Julia Volaufova and Bruce A. Bennett and Stuart Chalew and William T. Cefalu and Melinda Sothern},
  journal={Diabetologia},
  year={2010},
  volume={54},
  pages={869-875}
}
We hypothesised that ectopic fat deposition is present in liver and skeletal muscle before puberty and that both are potentially important factors in the early pathogenesis of insulin resistance. Proton magnetic resonance spectroscopy was used to evaluate intramyocellular and intrahepatic lipids in 50 male and 42 female multi-ethnic, prepubertal (Tanner < 2) children (8.1 ± 0.8 years; 35.4 ± 10.7 kg; 27.9 ± 8.3% body fat; means ± SD). Intramyocellular lipid was measured in soleus muscle and… CONTINUE READING
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