Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease.

  title={Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease.},
  author={Alfonso Tan-Garcia and Lu-En Wai and Dahai Zheng and Erica Ceccarello and Juandy Jo and Nasirah Banu and Atefeh Khakpoor and Adeline S E Chia and Christine Y L Tham and A. T. Tan and M. L. Hong and Choong Tat Keng and Laura Rivino and Kai Chah Tan and Kang Hoe Lee and Seng Gee Lim and Vincenzo W Cerundolo and Norman Pavelka and Jinmiao Chen and Florent Ginhoux and Qingfeng Chen and Antonio Bertoletti and C A Dutertre},
  journal={Journal of hepatology},
  volume={67 3},
BACKGROUND & AIMS Liver inflammation is key in the progression of chronic viral hepatitis to cirrhosis and hepatocellular carcinoma. The magnitude of viral replication and the specific anti-viral immune responses should govern the degree of inflammation, but a direct correlation is not consistently found in chronic viral hepatitis patients. We aim to better define the mechanisms that contribute to chronic liver inflammation. METHODS Intrahepatic CD14+ myeloid cells from healthy donors (n=19… CONTINUE READING
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