Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils.

  title={Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils.},
  author={Rossana C N Melo and Sandra Aurora Chavez Perez and Lisa A Spencer and Ann M. Dvorak and Peter F. Weller},
  volume={6 10},
Eosinophils, leukocytes involved in allergic, inflammatory and immunoregulatory responses, have a distinct capacity to rapidly secrete preformed granule-stored proteins through piecemeal degranulation (PMD), a secretion process based on vesicular transport of proteins from within granules for extracellular release. Eosinophil-specific granules contain cytokines and cationic proteins, such as major basic protein (MBP). We evaluated structural mechanisms responsible for mobilizing proteins from… CONTINUE READING
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