Intragraft levels of Foxp3 mRNA predict progression in renal transplants with borderline change.

@article{Mansour2008IntragraftLO,
  title={Intragraft levels of Foxp3 mRNA predict progression in renal transplants with borderline change.},
  author={Hicham Mansour and S{\'e}bastien Homs and Dominique Desvaux and C{\'e}cile Badoual and Karine Y Dahan and M de Go{\"u}yon Matignon and Vincent Audard and Philippe Lang and Philippe Grimbert},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2008},
  volume={19 12},
  pages={2277-81}
}
The optimal therapeutic management of borderline lymphocytic infiltrates in renal allografts, described by Banff criteria, is unknown, largely because of the inability to predict clinical outcome in these cases. For determination of molecular factors that may predict outcome in cases of borderline change histology, mRNA levels of Foxp3, Granzyme B, IFN-gamma, IL-23, and RORgammat were measured in renal tissue from 46 untreated patients. Twenty-five patients were considered "nonprogressive… CONTINUE READING

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