Intraglandular transplantation of bone marrow-derived clonal mesenchymal stem cells for amelioration of post-irradiation salivary gland damage.

@article{Lim2013IntraglandularTO,
  title={Intraglandular transplantation of bone marrow-derived clonal mesenchymal stem cells for amelioration of post-irradiation salivary gland damage.},
  author={Jae-Yol Lim and Tacghee Yi and Jeong-Seok Choi and Yun Ho Jang and Songyi Lee and Hun Kim and Sun Uk Song and Young-Mo Kim},
  journal={Oral oncology},
  year={2013},
  volume={49 2},
  pages={136-43}
}
OBJECTIVES External irradiation in head and neck cancers may induce irreversible hyposalivation and consequent xerostomia, stemming from radiation damage to salivary glands (SGs). As cell-based therapy has been reported to be able to repair or restore damaged SG tissues, we attempted to determine whether bone marrow-derived clonal mesenchymal stem cells (BM-cMSCs) can ameliorate irradiation-induced salivary gland damage via a murine model. METHODS External irradiation at a dose of 15Gy was… CONTINUE READING
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