Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition.

@article{Stamey1995IntragenomicLA,
  title={Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition.},
  author={Felicia R Stamey and Geraldina Dominguez and Jodi B Black and Timothy R. Dambaugh and Philip E. Pellett},
  journal={Journal of virology},
  year={1995},
  volume={69 1},
  pages={589-96}
}
We identified some passage lineages of human herpesvirus 6 variant B (HHV-6B) strain Z29 that contain as many as 12 tandem copies of a genomic segment that corresponds almost precisely to a previously identified minimal efficient origin of lytic replication (oriLyt). Analysis of nucleotide sequences in the vicinity of the amplified segment suggests that the amplification occurred as a two-step process, with the first step being a rare sequence duplication mediated through directly repeated… CONTINUE READING

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Human herpesvirus 6.

Clinical microbiology reviews • 1997
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