Intragenic tandem repeats generate functional variability

  title={Intragenic tandem repeats generate functional variability},
  author={Kevin J Verstrepen and An Jansen and Fran Lewitter and Gerald Fink},
  journal={Nature Genetics},
Tandemly repeated DNA sequences are highly dynamic components of genomes. Most repeats are in intergenic regions, but some are in coding sequences or pseudogenes. In humans, expansion of intragenic triplet repeats is associated with various diseases, including Huntington chorea and fragile X syndrome. The persistence of intragenic repeats in genomes suggests that there is a compensating benefit. Here we show that in the genome of Saccharomyces cerevisiae, most genes containing intragenic… CONTINUE READING
Highly Influential
This paper has highly influenced 21 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 249 extracted citations

Evolution of Protein Domain Repeats in Metazoa

Molecular biology and evolution • 2016
View 6 Excerpts
Highly Influenced

Genetic diversity of FLO1 and FLO5 genes in wine flocculent Saccharomyces cerevisiae strains.

International journal of food microbiology • 2014
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 33 references

Molecular origins of rapid and continuous morphological evolution.

Proceedings of the National Academy of Sciences of the United States of America • 2004

a new way towards wine strain characterisation

P. Marinangeli, D. Angelozii, +3 authors M. Minisatellites in Saccharomyces cerevisiae genes e proteins
FEMS Yeast Res. 4, 427–435 • 2004

Similar Papers

Loading similar papers…