Intragenic tandem repeats generate functional variability

@article{Verstrepen2005IntragenicTR,
  title={Intragenic tandem repeats generate functional variability},
  author={Kevin J Verstrepen and An Jansen and Fran Lewitter and Gerald Fink},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={986-990}
}
Tandemly repeated DNA sequences are highly dynamic components of genomes. Most repeats are in intergenic regions, but some are in coding sequences or pseudogenes. In humans, expansion of intragenic triplet repeats is associated with various diseases, including Huntington chorea and fragile X syndrome. The persistence of intragenic repeats in genomes suggests that there is a compensating benefit. Here we show that in the genome of Saccharomyces cerevisiae, most genes containing intragenic… CONTINUE READING
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