Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population

@article{Qi2004IntragenicLD,
  title={Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population},
  author={Lu Qi and E. Shyong Tai and Chee Eng Tan and Haiqing Shen and Suok Kai Chew and Andrew S Greenberg and Dolores Corella and Jos{\'e} M. Ordov{\'a}s},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={83},
  pages={448-456}
}
Perilipin is a lipid droplet surface protein present in adipocytes and steroidogenic cells. We examined five common single nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus (PLIN 6209C>T, 10171A>T, 11482G>A, 13041A>G, and 14995A>T) to investigate their association with obesity risk. The study population included 4,131 subjects of three ethnic groups (Chinese, Malay, and Indian) from Singapore. The prevalence of obesity in Malays and Indians was much higher than in Chinese. Moreover… CONTINUE READING