Intragenic Recombination Has a Critical Role on the Evolution of Legionella pneumophila Virulence-Related Effector sidJ

@inproceedings{Csta2014IntragenicRH,
  title={Intragenic Recombination Has a Critical Role on the Evolution of Legionella pneumophila Virulence-Related Effector sidJ},
  author={Joana C{\'o}sta and Paulo Gonçalves Teixeira and Ana Filipa d'Av{\'o} and C{\'e}lio Santos J{\'u}nior and Ant{\'o}nio Ver{\'i}ssimo and Yousef Abu Kwaik},
  booktitle={PloS one},
  year={2014}
}
SidJ is a Dot/Icm effector involved in the trafficking or retention of ER-derived vesicles to Legionella pneumophila vacuoles whose mutation causes an observable growth defect, both in macrophage and amoeba hosts. Given the crucial role of this effector in L. pneumophila virulence we investigated the mechanisms shaping its molecular evolution. The alignment of SidJ sequences revealed several alleles with amino acid variations that may influence the protein properties. The identification of HGT… CONTINUE READING
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References

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Showing 1-10 of 102 references

Verı́ssimo A (2010) Molecular evolution of Legionella pneumophila dotA gene, the contribution of natural environmental strains

J Costa, I Tiago, MS da Costa
Environ Microbiol • 2010
View 7 Excerpts
Highly Influenced

Legionella secreted effectors and innate immune responses.

Cellular microbiology • 2012
View 5 Excerpts
Highly Influenced

Molecular pathogenesis of infections caused by Legionella pneumophila

HJ Newton, DK Ang, IR van Driel, EL Hartland
Clin Microbiol Rev • 2010
View 4 Excerpts
Highly Influenced

Comparison of clinical and environmental samples of Legionella pneumophila at the nucleotide sequence level.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases • 2009
View 5 Excerpts
Highly Influenced

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