Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats.

Abstract

The neuropathological hallmark of idiopathic Parkinson's disease (PD) is dopaminergic neuron degeneration in the substantia nigra. However, it has been suggested that the neurodegenerative process initially may occur in the dorsal motor nucleus of the vagus (DMV). This implies that unidentified environmental toxins or neurotropic pathogens that is capable… (More)

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@article{Miwa2006IntragastricPI, title={Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats.}, author={Hideto Miwa and Tomomi Kubo and Ai Suzuki and Tomoyoshi Kondo}, journal={Neuroscience letters}, year={2006}, volume={401 1-2}, pages={146-9} }