Intragastric immunization with recombinant Lactobacillus casei expressing flagellar antigen confers antibody-independent protective immunity against Salmonella enterica serovar Enteritidis.

@article{Kajikawa2007IntragastricIW,
  title={Intragastric immunization with recombinant Lactobacillus casei expressing flagellar antigen confers antibody-independent protective immunity against Salmonella enterica serovar Enteritidis.},
  author={Akinobu Kajikawa and Eiichi Satoh and Rob J. Leer and Shigeki Yamamoto and Shizunobu Igimi},
  journal={Vaccine},
  year={2007},
  volume={25 18},
  pages={3599-605}
}
A recombinant Lactobacillus casei expressing a flagellar antigen from Salmonella enterica serovar Enteritidis was constructed and evaluated as a mucosal vaccine. Intragastric immunization of the recombinant strain conferred protective immunity against Salmonella infection in mice. This immunization did not result in antigen-specific antibody in either feces or sera but induced the release of IFN-gamma on restimulation of primed lymphocytes ex vivo. The results suggested that the protective… CONTINUE READING