Intragastric immunization of mice with enterohemorrhagic Escherichia coli O157:H7 bacterial ghosts reduces mortality and shedding and induces a Th2-type dominated mixed immune response.

@article{Cai2010IntragastricIO,
  title={Intragastric immunization of mice with enterohemorrhagic Escherichia coli O157:H7 bacterial ghosts reduces mortality and shedding and induces a Th2-type dominated mixed immune response.},
  author={Kun Cai and Xiang Gao and Tao Li and Xiaojun Hou and Qin Wang and Hao Liu and Le Xiao and Wei Hong Tu and Yuenan Liu and Jing Shi and Hui Wang},
  journal={Canadian journal of microbiology},
  year={2010},
  volume={56 5},
  pages={389-98}
}
A bacterial ghost (BG)-based vaccine was developed against enterohemorrhagic Escherichia coli O157:H7 infection. The aim of this study was to evaluate the protective effect of E. coli O157:H7 BGs in a mouse model and to reveal the mechanism of the immune response. Booster immunization provided a higher protection rate (84%) than single-dose immunization (56%). Intragastric immunization of E. coli O157:H7 BGs induced both humoral and cellular immune responses. The proliferative response of CD4… CONTINUE READING
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