Intragastric distribution of ion-exchange resins: a drug delivery system for the topical treatment of the gastric mucosa.

@article{Burton1995IntragastricDO,
  title={Intragastric distribution of ion-exchange resins: a drug delivery system for the topical treatment of the gastric mucosa.},
  author={Shelley Burton and Neena Washington and Robert J. C. Steele and Rhiannon Musson and Liam C. Feely},
  journal={The Journal of pharmacy and pharmacology},
  year={1995},
  volume={47 11},
  pages={901-6}
}
Previous studies by this group on freeze-dried oral dosage forms containing finely-divided ion-exchange resins revealed prolonged gastric residence and uniform distribution within the stomach. The present study was carried out to ascertain whether this was due to freeze-drying, properties of the radiolabelled ionic exchange resin, or the small dosing volume used. 99mTc-labelled cholestyramine resin was administered in two dosage forms, a freeze-dried tablet which dissolved in the oral cavity… CONTINUE READING
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