Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice.

@article{Mori2011IntragastricAO,
  title={Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice.},
  author={Noriyuki Mori and Fuminori Kawabata and Shigenobu Matsumura and Hiroshi Hosokawa and Shigeo Kobayashi and Kazuo Inoue and Tohru Fushiki},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={300 6},
  pages={
          R1494-505
        }
}
  • N. Mori, Fuminori Kawabata, +4 authors T. Fushiki
  • Published 1 June 2011
  • Biology, Chemistry
  • American journal of physiology. Regulatory, integrative and comparative physiology
The transient receptor potential (TRP) channel family is composed of a wide variety of cation-permeable channels activated polymodally by various stimuli and is implicated in a variety of cellular functions. Recent investigations have revealed that activation of TRP channels is involved not only in nociception and thermosensation but also in thermoregulation and energy metabolism. We investigated the effect of intragastric administration of TRP channel agonists on changes in energy substrate… 
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27 Citations

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Citation Type

Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1
TLDR
It is suggested that intragastric administration of AITC could induce insulin secretion from islets via TRPV1 and that enhancement of insulin secretion was related to the increased carbohydrate oxidation due to A ITC.
Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice
TLDR
Intragastric administration of AMG517, a TRPV1 antagonist, increases locomotor activity and enhances energy metabolism via capsaicin-sensitive sensory nerves in mice, including vagal afferents.
Differences in the effects of TRPV1 antagonists on energy metabolism in mice.
TLDR
It is shown that intragastric administration of AMG517, a nonselective antagonist of TRPV1 (for heat, protons and capsaicin), enhanced energy metabolism as much as did intraperitoneal administration, and the type of TRpV1 antagonists and the routes of its administration have different effects on energy metabolism in a normal body.
Comparative analysis of allyl isothiocyanate (AITC)-induced carbohydrate oxidation changes via TRPV1 between mice and chickens.
TLDR
A comparative study using chickens and mice suggested that the capsaicin-binding site is an important region for increasing carbohydrate oxidation by AITC administration in animals.
Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach
TLDR
The results suggest that capsaicin acts on the heat receptor incockroaches and that TRP receptors are involved in cockroaches’ thermosensation.
Intragastric administration of allyl isothiocyanate reduces hyperglycemia in intraperitoneal glucose tolerance test (IPGTT) by enhancing blood glucose consumption in mice.
TLDR
It is suggested that dietary AITC might reduce the increases in blood glucose levels by increasing the utilization of excessive glucose in the blood by activating TRPV1.
Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1,8-cineole via TRPM8 in mice
Investigation of the transient receptor potential vanilloid 1 (TRPV1) ion channel
TLDR
Sensory modalities that may be lost after the RTX treatment of newborn or adult mice are determined, and TRPA1 expression is coincident with TRPV1 expression in the vast majority of nociceptive neurons that normally confer pain signal to endogenous substances produced in pain and inflammation.
Mammalian transient receptor potential TRPA1 channels: from structure to disease.
TLDR
The current knowledge about the mammalian TRPA1 channel is reviewed, linking its unique structure, widely tuned sensory properties and complex regulation to its roles in multiple pathophysiological conditions.
No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men
TLDR
The highest tolerable dose of mustard used did not elicit a relevant thermogenic response in humans and no differences in substrate oxidation, core temperature, cold and hunger scores, or plasma parameters were found, nor was the energy intake at the end of the experiment different between the 3 conditions.
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References

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TLDR
The results suggest that TRPA1 agonists activate the sensory nerves and induce adrenaline secretion via the central nervous system.
Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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