Intraflagellar transport

@article{Rosenbaum2002IntraflagellarT,
  title={Intraflagellar transport},
  author={Joel L. Rosenbaum and George B. Witman},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={813-825}
}
Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project from the surfaces of many cells. The assembly and maintenance of these nearly ubiquitous structures are dependent on a transport system — known as 'intraflagellar transport' (IFT) — which moves non-membrane-bound particles from the cell body out to the tip of the cilium or flagellum, and then returns them to the cell body. Recent results indicate that defects in IFT might be a… Expand
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TLDR
An overview of the main cytoskeletal structures associated with cilia and centrioles are presented with emphasis on the MT-associated appendages, fibers, and filaments at the cilium base and tip with possible functions in relation to cilia assembly, disassembly, and length regulation. Expand
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TLDR
Functional and phylogenetic analyses reveal that at least seven kinesin families are involved in flagellum assembly and function, and this diversity of function in protists is also observed. Expand
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TLDR
This chapter reviews the current understanding of the various mechanisms involved in cilia and flagellar assembly and maintenance and discusses several major ciliopathies including primary ciliary dyskinesia, hydrocephalus, polycystic kidney disease, Bardet-Biedl syndrome, and cancer. Expand
Swimming with protists: perception, motility and flagellum assembly
TLDR
Energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence are discussed. Expand
Protein transport in growing and steady‐state cilia
TLDR
Recent data on cues regulating the type, amount and timing of cargo transported by IFT are discussed, suggesting a regulation of IFT‐cargo interactions is critical to establish, maintain and adjust ciliary length, protein composition and function. Expand
Electron microscopy of flagella, primary cilia, and intraflagellar transport in flat-embedded cells.
TLDR
The focus of this chapter is to describe the application of the flat embedding technique to Chlamydomonas reinhardtii and monolayers of mammalian culture cells, well suited for the analysis of the ultrastructure of the IFT system by standard electron microscopy and electron tomography. Expand
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