Intraflagellar transport

@article{Rosenbaum2002IntraflagellarT,
  title={Intraflagellar transport},
  author={Joel L. Rosenbaum and George B. Witman},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={813-825}
}
Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project from the surfaces of many cells. The assembly and maintenance of these nearly ubiquitous structures are dependent on a transport system — known as 'intraflagellar transport' (IFT) — which moves non-membrane-bound particles from the cell body out to the tip of the cilium or flagellum, and then returns them to the cell body. Recent results indicate that defects in IFT might be a… 

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Functional and phylogenetic analyses reveal that at least seven kinesin families are involved in flagellum assembly and function, and this diversity of function in protists is also observed.

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TLDR
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TLDR
Energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence are discussed.

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TLDR
Recent data on cues regulating the type, amount and timing of cargo transported by IFT are discussed, suggesting a regulation of IFT‐cargo interactions is critical to establish, maintain and adjust ciliary length, protein composition and function.

19 Biology of Cilia and Ciliopathies

TLDR
This chapter reviews the current understanding of the various mechanisms involved in cilia and flagellar assembly and maintenance and discusses several major ciliopathies including primary ciliary dyskinesia, hydrocephalus, polycystic kidney disease, Bardet-Biedl syndrome, and cancer.
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