Intraesophageal acid perfusion sensitizes the esophagus to mechanical distension: a Barostat study

  title={Intraesophageal acid perfusion sensitizes the esophagus to mechanical distension: a Barostat study},
  author={Wayne Hsing Cheng Hu and Christopher J. Martin and Nicholas J Talley},
  journal={American Journal of Gastroenterology},
OBJECTIVE:The pathogenesis of noncardiac chest pain is unclear. Increased gastroesophageal reflux and decreased pain thresholds to intraesophageal balloon distension have been demonstrated in a proportion of such patients. We aimed to investigate whether acid exposure sensitizes esophageal mechanoreceptors in healthy volunteers.METHODS:After an overnight fast, an infinitely compliant balloon, 4.5 cm in length and mounted on a multilumen transnasal manometry catheter, was placed 8.5 cm above the… CONTINUE READING


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