Intraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone.

Abstract

Herein, we show that intraerythrocytic stages of Plasmodium falciparum have an active pathway for biosynthesis of menaquinone. Kinetic assays confirmed that plasmodial menaquinone acts at least in the electron transport. Similarly to Escherichia coli, we observed increased levels of menaquinone in parasites kept under anaerobic conditions. Additionally, the mycobacterial inhibitor of menaquinone synthesis Ro 48-8071 also suppressed menaquinone biosynthesis and growth of parasites, although off-targets may play a role in this growth-inhibitory effect. Due to its absence in humans, the menaquinone biosynthesis can be considered an important drug target for malaria.

DOI: 10.1016/j.febslet.2010.10.055

Cite this paper

@article{Tonhosolo2010IntraerythrocyticSO, title={Intraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone.}, author={Renata Tonhosolo and Heloisa B. Gabriel and Miriam Y Matsumura and Fernanda Janku Cabral and M{\'a}rcio Massao Yamamoto and Fabio Luiz D'Alexandri and Rodrigo Antonio Ceschini Sussmann and Rodrigo C. Belmonte and Valnice Jesus Peres and Dean C. Crick and Gerhard Wunderlich and Em{\'i}lia Akemi Kimura and Alejandro Miguel Katzin}, journal={FEBS letters}, year={2010}, volume={584 23}, pages={4761-4768} }