Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter.

@article{Woodrow1999IntraerythrocyticPF,
  title={Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter.},
  author={Charles J Woodrow and Jeffrey I Penny and Sanjeev Krishna},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 11},
  pages={7272-7}
}
Asexual stages of Plasmodium falciparum cause severe malaria and are dependent upon host glucose for energy. We have identified a glucose transporter of P. falciparum (PfHT1) and studied its function and expression during parasite development in vitro. PfHT1 is a saturable, sodium-independent, and stereospecific transporter, which is inhibited by cytochalasin B, and has a relatively high affinity for glucose (Km = 0.48 mM) when expressed in Xenopus laevis oocytes. Competition experiments with… CONTINUE READING

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