Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine.

@article{Kunisawa2007IntraepithelialLT,
  title={Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine.},
  author={Jun Kunisawa and Ichiro Takahashi and Hiroshi Kiyono},
  journal={Immunological reviews},
  year={2007},
  volume={215},
  pages={136-53}
}
At the front line of the body's immunological defense system, the gastrointestinal tract faces a large number of food-derived antigens, allergens, and nutrients, as well as commensal and pathogenic microorganisms. To maintain intestinal homeostasis, the gut immune system regulates two opposite immunological reactions: immune activation and quiescence. With their versatile immunological features, intraepithelial lymphocytes (IELs) play an important role in this regulation. IELs are mainly… CONTINUE READING