Intraepithelial current flow in rat pancreatic secretory epithelia

  title={Intraepithelial current flow in rat pancreatic secretory epithelia},
  author={L. A. R. Evans and D. Pirani and David I. Cook and John Atherton Young},
  journal={Pfl{\"u}gers Archiv},
To assess the importance for transepithelial salt secretion of current flow across the baso-lateral membrane, we studied the effects of ouabain (1 mmol/l), Ba (3 mmol/l) and tetraethylammonium (TEA: 10 mmol/l) on secretion by the acinar (caerulein stimulated) and ductal (secretin stimulated) epithelia of the perfused rat pancreas. Within 10 min, ouabain caused a 79% inhibition of acinar secretion which was resolvable into two exponentials with half-times, respectively, of 0.24 min±0.19 (S.D… CONTINUE READING
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