Intraepithelial and postinvasive neoplasia as a stochastic continuum of clonal evolution, and its relationship to mechanisms of chemopreventive drug action.

@article{Boone1993IntraepithelialAP,
  title={Intraepithelial and postinvasive neoplasia as a stochastic continuum of clonal evolution, and its relationship to mechanisms of chemopreventive drug action.},
  author={Charles W. Boone and Gary j. Kelloff and Laurence S Freedman},
  journal={Journal of cellular biochemistry. Supplement},
  year={1993},
  volume={17G},
  pages={14-25}
}
The progression of intraepithelial and postinvasive neoplasia depends on the occurrence of clonal evolution, defined as the continuous development of mutations and selective clonal expansions in the neoplastic cell population. The two continuously repeating events of clonal evolution, mutation and clonal expansion, occur at unpredictable times and locations. Therefore the neoplastic process is best characterized as a stochastic, i.e., probabilistic, continuum. The rate of intraepithelial… CONTINUE READING