Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship

@article{Kindelberger2007IntraepithelialCO,
  title={Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship},
  author={David W. Kindelberger and Yonghee Lee and Alexander Miron and Michelle S. Hirsch and Colleen M. Feltmate and Fabiola Medeiros and Michael J. Callahan and Elizabeth I. O. Garner and Robert W. Gordon and Chandler Birch and Ross S Berkowitz and Michael G. Muto and Christopher P. Crum},
  journal={The American Journal of Surgical Pathology},
  year={2007},
  volume={31},
  pages={161-169}
}
Proposed origins of pelvic serous carcinoma include the ovary, fallopian tube, and peritoneum. Prophylactic salpingo-oophorectomies in BRCA+ women have recently identified the fimbria as a site of origin for early serous carcinoma (tubal intraepithelial carcinoma or TIC). We explored the relationship of TIC to pelvic serous carcinomas in consecutive cases with complete adnexal exam (SEE-FIM protocol). Cases positive (group A) or negative (group B) for endosalpinx (including fimbria) involvement… 

Are All Pelvic (Nonuterine) Serous Carcinomas of Tubal Origin?

The findings, showing that nearly 60% of high-grade pelvic (nonuterine) serous carcinomas are associated with STICs, are consistent with the proposal that the fallopian tube is the source of a majority of these tumors.

Evaluation of the Fallopian Tubes After Neoadjuvant Chemotherapy: Persistence of Serous Tubal Intraepithelial Carcinoma

  • E. ColónJ. Carlson
  • Medicine
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 2014
This study addresses the presence or absence of STIC in specimens from interval surgery after neoadjuvant treatment, and indicates that STIC can persist despite chemotherapy and can be readily identified during microscopic examination.

Serous Tubal Intraepithelial Carcinoma and the Dominant Ovarian Mass: Clues to Serous Tumor Origin?

There is a significant inverse relationship between DOM+ and STIC (P=0.001), indicating both parameters are of value in grouping pelvic serous carcinomas more likely to be ovarian [DOM+/FIM(−)] versus fimbrial [DOM(−)/STIC], and ovarian or peritoneal surface (DOM−/Fim−) in origin.

Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention.

  • J. CarlsonA. Miron C. Crum
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
The fimbria is the source of nearly one half of PPSCs, suggesting serous malignancy originates in the tubal mucosa but grows preferentially at a remote peritoneal site.

Serous tubal intraepithelial carcinoma, chronic fallopian tube injury, and serous carcinoma development

No correlation with chronic tubal injury or inflammation was identified, and the incidence of serous tubal intraepithelial carcinoma (STIC) was examined in relation to other clinical parameters and whether chronic fallopian tube injury was related to cancer development.

Serous Tubal Intraepithelial Carcinoma Associated With Extraovarian Metastases

The data suggest that STIC should be regarded as a malignant lesion with metastatic potential and recommend a comprehensive surgical staging including lymphadenectomy.

A case of non-invasive serous adenocarcinoma at unilateral fimbria with spread to the peritoneal/uterine cavity: case report

A 67-year-old woman with non-invasive serous adenocarcinoma located solely in the left fimbria is described, which may suggest the benefit of endometrial cytology and detailed gross examination offimbria for the early detection of fimbrial carcinoma.

Intercepting early pelvic serous carcinoma by routine pathological examination of the fimbria

Incidentally discovered carcinomas underscore the potential risk, albeit low, of concurrent unsuspected malignancy in the distal fallopian tube and emphasize the importance of routine pathological examination of the fimbria in all salpingectomies.

Coexisting Intraepithelial Serous Carcinomas of the Endometrium and Fallopian Tube: Frequency and Potential Significance

  • E. JarboeA. Miron M. Nucci
  • Medicine
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 2009
It is shown that noninvasive, genetically related serous carcinomas may coexist in both tube and endometrium, and that tumors with concurrent STIC be classified as a distinct subset of pelvic serious carcinomas pending a clearer understanding of tumor origin.

Serous tubal intraepithelial carcinoma (STIC) – clinical impact and management

Methods of STIC diagnostics are investigated, available knowledge on surgical management, adjuvant chemotherapy and subsequent follow-up procedure in women with an isolated STIC are presented, and patients found to have an incidental STIC lesion are referred for screening of BRCA1/2 mutation.
...

References

SHOWING 1-10 OF 34 REFERENCES

The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome

The fimbria was the most common location for early serous carcinoma in this series of BRCA-positive women, and Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarianSerous carcinomas.

Intraperitoneal serous adenocarcinoma: a critical appraisal of three hypotheses on its cause.

Minimal uterine serous carcinoma: diagnosis and clinicopathologic correlation.

The clinicopathologic features of uterine serous carcinoma (USC) lacking myometrial invasion, including its putative precursor lesion endometrial intraepithelial carcinoma (EIC), have not been

Advances in the Recognition of Tubal Intraepithelial Carcinoma: Applications to Cancer Screening and the Pathogenesis of Ovarian Cancer

This review addresses a multitude of epithelial changes; benign, malignant, and an intriguing third group, which the authors term “p53 signatures,” is found in benign, nonciliated epithelium and stain intensely positive for p53.

Extraovarian peritoneal serous papillary carcinoma. A clinicopathologic study of 31 cases

The rate and clinical features of patients admitted to King George V Hospital with extraovarian peritoneal serous papillary carcinoma during a 9‐year period were reviewed and there was no difference in actuarial survival.

Molecular evidence for multifocal papillary serous carcinoma of the peritoneum in patients with germline BRCA1 mutations.

BACKGROUND Papillary serous carcinoma of the peritoneum (PSCP) diffusely involves peritoneal surfaces, while it spares or only superficially involves the ovaries. PSCP is histologically

Tumors of the Fimbriated End of the Fallopian Tube: A Clinicopathologic Analysis of 20 Cases, Including Nine Carcinomas

It appears that carcinomas confined to the fimbriae may have a worse prognosis than Stage I tubal tumors that are nonfimbrial, and it is proposed that they be placed in a new category, Stage I(F), because the tumor cells are exposed directly to the peritoneal cavity even though they do not invade the tubal wall.

Endometrial intraepithelial carcinoma with associated peritoneal carcinomatosis.

It is concluded that the finding of EIC in an endometrial curettage specimen should prompt a thorough search for an invasive uterine and/or extrauterine serous carcinoma, and anendometrial origin should be excluded in patients with peritoneal carcinomatosis.

Occult Carcinoma in Prophylactic Oophorectomy Specimens: Prevalence and Association With BRCA Germline Mutation Status

Occult carcinoma is present in a small proportion of BRCA-positive or unknown PO patients and may be of prognostic significance and the entire ovaries and tubes from PO patients should be submitted for histologic examination to identify malignancy.

A candidate precursor to serous carcinoma that originates in the distal fallopian tube (J Pathol 2007; 211: 26–35)

The p53 signature and its malignant counterpart (TIC) underline the significance of the fimbria, both as a candidate site for serous carcinogenesis and as a target for future research on the early detection and prevention of this disease.