Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients.

@article{Pittenger2004IntraepidermalNF,
  title={Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients.},
  author={Gary L. Pittenger and Madhumita Ray and Niculina I. Burcus and Patricia McNulty and Baher Basta and Aaron I Vinik},
  journal={Diabetes care},
  year={2004},
  volume={27 8},
  pages={1974-9}
}
OBJECTIVE Small-fiber neuropathies may be symptomatic yet escape detection by standard tests. We hypothesized that morphologic changes in intraepidermal nerves would correlate with clinical measures of small-fiber neuropathy. RESEARCH DESIGN AND METHODS We studied 25 diabetic and 23 nondiabetic patients with neuropathy defined by signs, symptoms, and quantitative testing and 20 control subjects. Skin biopsies were obtained from forearm, thigh, proximal leg, and distal leg, and nerves… CONTINUE READING
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  • JW Griffin, JC McArthur, M Polydefkis
  • 2002

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