Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline.

@article{BoyetteDavis2011IntraepidermalNF,
  title={Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline.},
  author={Jessica A. Boyette-Davis and Wen-Jun Xin and Hong-Xing Zhang and Patrick M Dougherty},
  journal={Pain},
  year={2011},
  volume={152 2},
  pages={308-13}
}
Loss of intraepidermal nerve fibers (IENFs) has been speculated to play a critical role in the development of various neuropathies. In this study, the density of IENFs were studied over time during the induction of Taxol (Bristol-Myers Squibb, NY, USA)-induced chemoneuropathy and compared with the changes in IENFs in animals co-treated with Taxol plus the protective agent minocycline. Rats were injected (intraperitoneally) with 2mg/kg of Taxol every other day for four injections (day 1, 3, 5… CONTINUE READING
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