Intraepidermal nerve fiber density in patients with painful sensory neuropathy.

@article{Holland1997IntraepidermalNF,
  title={Intraepidermal nerve fiber density in patients with painful sensory neuropathy.},
  author={Neil R. Holland and Andrea Stocks and Peter E Hauer and David Reid Cornblath and John Wesley Griffin and Justin C. Mcarthur},
  journal={Neurology},
  year={1997},
  volume={48 3},
  pages={708-11}
}
Despite prominent symptoms of neuropathic pain, patients with small-fiber sensory neuropathies have few objective abnormalities on clinical examination and routine electrodiagnostic studies. We quantified intraepidermal nerve fiber (IENF) density in sections of skin obtained by punch skin biopsy, and found it to be significantly reduced in patients with painful sensory neuropathies compared with age-matched control subjects. In addition, IENF density correlated with clinical estimates of… CONTINUE READING