Intraduodenal infusion of a combination of tastants decreases food intake in humans.

@article{Avesaat2015IntraduodenalIO,
  title={Intraduodenal infusion of a combination of tastants decreases food intake in humans.},
  author={Mark van Avesaat and Freddy J. Troost and Dina Ripken and Jelmer Peters and Henk F. J. Hendriks and Ad Am Masclee},
  journal={The American journal of clinical nutrition},
  year={2015},
  volume={102 4},
  pages={729-35}
}
BACKGROUND Taste receptors are expressed not only in taste buds but also in the gastrointestinal tract. It has been hypothesized that these receptors may play a role in satiety and food intake. OBJECTIVE This study investigated the effect of intraduodenal tastant infusions (bitter, sweet, and umami) on food intake, hunger and fullness, gastrointestinal symptoms, and gastrointestinal peptide release. DESIGN Fifteen healthy volunteers [6 male; mean ± SEM age: 23.9 ± 2.0 y; mean ± SEM body… CONTINUE READING

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The bitter taste receptor agonist denatonium benzoate alters intragastric pressure profiles during nutrient drink test in healthy volunteers

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The bitter taste receptor agonist denatonium benzoate alters intragastric pressure profiles during nutrient drink test in healthy volunteers. Gastroenterology 2013;144(Suppl 1):S-549

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