Intraductal carcinoma is the precursor of carcinoma ex pleomorphic adenoma and is often associated with dysfunctional p53.

@article{Ihrler2007IntraductalCI,
  title={Intraductal carcinoma is the precursor of carcinoma ex pleomorphic adenoma and is often associated with dysfunctional p53.},
  author={Stephan Ihrler and Christoph Weiler and Astrid Hirschmann and Andrea Sendelhofert and Stephan Lang and Orlando Guntinas-Lichius and Georg Arnold and Christian Zietz and John D Harrison},
  journal={Histopathology},
  year={2007},
  volume={51 3},
  pages={362-71}
}
AIMS Although intraductal carcinoma has been demonstrated in intracapsular carcinoma ex pleomorphic adenoma (CEPA), the morphological and genetic stages of transformation of pleomorphic adenoma (PA) to CEPA are not fully understood. The aim of this study was to investigate the morphology of intracapsular CEPA. METHODS AND RESULTS The largest series of intracapsular CEPA studied was subject to immunohistochemical double-staining to detect p53 protein and cellular proliferation in different… CONTINUE READING